Mother-to-child transmission of HIV in the Southern Region of Santa Catarina, from 2005 to 2015: analysis of risk factors to seroconversion in newborns
Abstract
Objectives: to analyze both frequency and risk factors for seroconversion among
newborns of HIV-positive mothers to HIV.
Methods: a cohort study was conducted with children residing in Southern Region of
Santa Catarina. Secondary data from the notification files and medical records of newborn’s
mothers of infected infants were used. The participants were all the newborns from 2005 to
2015 that were exposed to HIV through vertical transmission and attended a municipal health
care center.
Results: there were 104 cases of infant exposure to HIV. Seroconversion was confirmed in
three cases, two of them died of AIDS during the study period. Breastfeeding (PR= 32.7;
CI95%= 10.7-99.5; p= 0.002) and non-use of antiretroviral drugs during pregnancy
(PR=18.2; CI95%= 2.0-163.0; p= 0.008) were risk factors for HIV seroconversion.
Conclusions: seroconversion rates among neonates in Southern Region of Santa Catarina
were similar to the national average. Seroconversion was associated with non-use of antiretroviral
therapy during pregnancy and breastfeeding.
Keyword
HIV infectionsInfectious diseases transmission
vertical
Seroconversion
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